Thrombocytes (Platelets)
What is a thrombocyte
Thrombocytes are small blood components produced in the bone marrow with a key role in blood clotting. The main function of thrombocytes is to stop the bleeding of injured blood vessels. In mammals, thrombocytes are anucleated cell fragments called platelets.
Nucleated thrombocytes of nonmammalian vertebrates differ from mammalian thrombocytes not only in having a nucleus, resembling B lymphocytes, but also these nucleated thrombocytes do not aggregate in response to ADP, serotonin and adrenaline. They do aggregate with thrombin.
In response to vascular injury, thrombocytes gather at the site of the interrupted endothelium to help form blood clots, sticking to plug the impairment. Here’s a simplified account of the process:
1. Adhesion. Thrombocytes (platelets) bind to specific membrane receptors outside the interrupted endothelium.
2. Activation. A change in shape takes place, receptors become activated, and chemical messengers are secreted.
3. Aggregation. The activated thrombocytes (platelets) connect with each other. This happens through receptor bridges.
To put it simply, thrombocytes, which is more commonly known as platelets, is a blood component crucial to normal blood clotting.
Clot formation is the process where blood forms into a clot, which is an important part of hemostasis. Coagulation (thrombogenesis) is the hematologic undertaking by which blood changes into gel, eventually forming a blood clot. Hemostasis is the cessation of blood loss from the damaged blood vessel. In response to injury, the blood vessel wall becomes covered with platelet and fibrin-containing blood clot to stop the bleeding and begin the repair of the damaged vessel. Disorders in coagulation can either lead to increased risk of bleeding (hemorrhage) or obstructive clotting (thrombosis).
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