10 Mean Platelet Volume Significant Aspects

Mean Platelet Volume

What is Mean Platelet Volume

Mean platelet volume (MPV) is part of the Complete Blood Count (CBC) tests and it identifies the average size of platelets found in the blood of an individual.

The test is specifically used to show the relationship between the production of platelets in the bone marrow or incidence on the destruction of platelets.

Platelets are an important part of the blood that is involved in blood clotting process.

The following are crucial aspects to know about mean platelet volume.

MPV Blood Test

1. Mean platelet volume detects blood disorders

A platelet count is used in screening whether the body of a person is producing normal amounts of platelets or not.

For example, a low or high platelet count may hint that the individual has developed abnormal levels that could have resulted from a blood disorder or medical condition associated with the bone marrow where the cell fragments are produced.

In comparison to mean platelet volume, a person can be identified to have a health problem before it can be evident using a platelet count.

The main aim of carrying out these two tests is to detect health conditions of the blood especially in regards to platelets.

Abnormal results may either be mean platelet volume low or mean platelet volume high.


2. A normal MPV has a range of 7.5-11.5 femtoliters

A level of 7.5-11.5 femtoliters (this is one quadrillionth of a litre) is the normal range for mean platelet volume in most cases. This range is however, subject to many other factors.

In order to determine the most favourable range for specific individuals, there are factors that must be considered.  One factor includes things such as geographical aspects of the area where the individual resides. For instance, people in the Mediterranean region have shown to display a higher MPV than those in some other geographical regions.

3. High MPV with low platelet count leads to destruction of platelets

High Mean Platelet Volume (MPV) with a low platelet count results in a condition that leads to massive destruction of platelets in the blood. Conditions that may arise include immune thrombocytopenia, a condition in which the immune system of the individual abnormally fights the platelets when formed thus, destroying them.

In the same context, during pregnancy, a condition known as pre-eclampsia may be experienced. This is a condition in which the blood pressure of the individual is greatly elevated to abnormal levels. The condition however, gets better after the birth of the child and consequently gets normal after some time.

4. High MPV with normal platelet count is a sign of chronic myeloid leukaemia

High Mean Platelet Volume (MPV) with normal platelet count can be a sign of chronic myeloid leukaemia, a condition in which there is overproduction in a particular type of white blood cells.

A condition known as hyperthyroidism may also be evident when MPV is high with a normal platelet count. This is a condition in which there is excessive production of thyroid hormones.

When a High MPV is accompanied by a high platelet count, it’s an indication that the bone marrow is producing the platelets in excess.

5. Some drugs kill platelets leading to a low MPV

There are some cases in which the MPV is lower than the average level. A Low Mean Platelet Volume (MPV) mostly results from therapy that involves usage of drugs which are toxic to cells therefore, either directly killing the platelets or destroying the megakaryocytes cells in the bone marrow.

The megakaryocytes are a source for platelet production. When accompanied with normal platelet count, a low MPV indicates a chronic kidney failure. If the mean platelet volume level is accompanied by a high platelet count, it shows that the body cells have been infected or indicates that the person has a certain form of cancer.

6. High MPV may result to blood clumping

Abnormal MPV does not only help identify underlying conditions that merit further investigation or confirm medical conditions, but are also indicative of being a threat in itself.

A high MPV for instance, indicates that the amount of platelets in the blood is higher than the normal values therefore, implying that the platelets have a higher tendency of clotting and clumping together. This condition puts the person at risk to conditions such as cardiovascular diseases, stroke or thrombosis.

In such situations, aspirin can be prescribed for it has the ability to prevent clumping together of platelets to form clots.

7. Low MPV results in over bleeding

In some cases, the Mean Platelet Volume (MPV) may be way lower than the normal Mean Platelet Volume (MPV) therefore, indicating that the process of clotting may be impaired. Such persons should be advised of aspirin precautions.

8. MPV indicates how reactive the platelets are

Mean Platelet Volume can also be used to indicate how reactive and large the platelets can be. This is as a result of the level of the platelets turnover.

An elevated MPV is an indicator of larger and more reactive platelets which is likely to be a result of increased platelet turnover. This will represent a risk for overall vascular mortality including myocardial infarction.

It shows that those individuals with an increased MPV are more likely to end up with blood disorders that may consequently result in death.

9. MPV is useful as a prognostic marker

Mean Platelet Volume (MPV) can also be useful in the assessment of the outcomes of clinical conditions such as stroke and the ischemic bowel disease. It is used as a prognostic marker to show whether the outcomes of patients with these conditions will be favourable or unfavourable.

It has been noted that patients with a higher prevalence of previous stroke are the ones who have a mean platelet volume of more than 9.4Fl. A higher MPV is mostly seen as an indicator of poor outcome in patients with such conditions.

10. MPV is affected by some cardiovascular factors

Some cardiovascular risk factors such as smoking and hypertension can greatly influence MPV, based on the confounding factors like low-grade inflammation.  There is a confirmed correlation between an increased MPV and the risk of thrombosis.

High MPV is connected with various established risks, cardio- and cerebrovascular disorders, as well as low-grade inflammatory disorders prone to venous and arterial thrombosis.


From several medical research activities, it is evident that patients with an increased MPV of more than 11.01 fL are at higher risk of blood complications and death due to a condition called ischemic heart disease. Dangerous ratios usually result from obesity or smoking.


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