10 Factors That Influence Platelet Life Span

10 Factors That Influence Platelet Life Span

Platelets are cell fragments which are mainly an essential component when it comes to blood clotting and coagulation. The platelets along with the red blood cells and white blood cells, function together for the regulation and normal functioning of blood in our body. The blood cells have each of their own different life span as well as different functions.  Among these three, the platelets are the smallest but one of the most important factors in blood clotting. If the platelets don’t get regulated properly, such as when they don’t get renewed at normal intervals, then the blood dysfunction or disorder might occur.

The general lifespan of a platelet is about 10 days.  The normal platelet count in the human blood ranges from 150,000 to 450,000 per micro liter of blood. The platelet count varies in different locations and organs. But in cases of medical conditions, the platelets count may either increase or decrease in the blood. One of the most common condition of platelet count changes is the popularly known thrombocytopenia where the levels drop below normal. There are actually several reasons that may have resulted to the drop in platelets. In such condition, there will be a necessity for immediate medical help due to the risk for bleeding. Moreover, thrombocytopenia can also act as a catalyst to trigger other idle diseases in the body. So it is of utmost importance to maintaining and watching proper balanced diet to deal with a low platelet count. On the other hand, an abnormal increase in platelets which is also due to specific causes is referred to as thrombocytosis.


Platelets life span may depend on certain things that we do or experience in our life. They can be classified as the following:


One of the most important factors that determine a platelet life span is genetics. It has been found out through many researches that the normal platelet count in human blood is deeply associated with the genes. The life span of these platelets are also advanced and rooted in the way how a person lives and carries his lifestyle. Studies have shown that the lifestyle influences heredity or genes. The normal life span as we have read earlier is just about 10 days. But with genetic influence, this can either increase or decrease, accordingly.


Age is one of the prime factors that affects the life span of a person’s platelet in the blood. It does not only serve as one of the factors that determine platelet life span, but also affects the count of platelets. With the progressions of age, the capacity of body system and regulation gets reduced affecting the growth and formation of platelets in human blood. As age increases, the body’s ability to hold a 10 day platelet life span decreases.

Sialic acid:

Sialic acid plays a very crucial role in regulating the life span of platelets in the human blood. Among the rated 7 to 10 days, which is the regular time for platelet cycle, the sialic acid, helps to regular it to a bigger extent. Galatactose, which helps to determine the sialic acid presence, can rapidly change or alter the life spans of platelets. The functionalities of the sialic acid is not fully recognized, but have been found to have a very crucial role in the life span of platelets.

Prevalent diseases:

If a human body carries any medical condition that may be affecting platelets, then the life cycle of platelets will certainly gt affected. If the platelets are not produced enough to keep a balance with the death of platelets, the body suffer will from thrombocytopenia. In thrombocytopenia, the platelet count becomes visibly low, and the resultant medical disorder can lead to serious medical conditions.  Pregnancy is also another common factor that can lead to low platelet count, but normal platelet life span remains intact.

Food habits:

A person’s food habits and diet regime is also one of the most important factor that determines the platelet count as well as the life span of platelets. There are certain foods that can help increase platelet count as well as alter its life span. Foods such as green leafy vegetables, foods with high zinc and whole grain, keep platelets healthy and increase count.

Prolonged Medicine intake:

It is very much known to us that those popularly known pain killers, helps ease our pain for the time being, but in the long run, there are certain factors in our blood that are acutely affected by these medicines. The medicines, can have the capacity to directly create a negative impact on the blood and various other organs, especially if not monitored carefully. The composition of the blood can possibly get to an imbalanced state due to the effects of these medicines. With prolonged intake of pain relievers, it doesn’t just affect the platelets but can even lead to organ failure.

Bone Marrow:

The platelets are developed or produced inside the bone marrow. So if there comes a disorder associated with the bone marrow, the platelet life spans get affected and probably decreases.  In case of acute medical disorders like leukemia or other forms of cancer, the bone marrow is involved and so does the platelet count and life span.

Blood Transfusion:

Medical conditions that could have resulted from improper blood transfusion is one of the common factors that can influence the regulation and life span of platelets.

Also, blood transfusion may be given in cases of acute injury or for the purpose of any other blood related disorder in the body, but since it will be an injection of a foreign blood, there may be body reaction resulting to tendencies on platelet life span changes.

Congenital thrombocytopenia:

In cases of this platelet related medical disorder of congenital thrombocytopenia, the platelet count becomes lower than the normal range. It even drops down to a range of about 100,000 per micro liters of blood. This make the body fail to maintain a proper life circulation rate of platelet from 7 to 10 days, and instead decreased to 5 days or less.

Abnormal accumulation of cells:

If in any part of the body where cells gets accumulated abnormally, the platelet count and its life cycle can potentially be impaired. The accumulation is mostly common in and around the bone marrow which makes the life span of platelet lower and ineffective.


We now have find out what and how does these factors influence or gets associated with the growth and regulation of platelets in the blood. The platelets are one of the most important part of the human body where any abnormal changes can result to undesirable results. Check out the diagnostic procedures to detect abnormal platelet count. Above are factors that can be either controlled or not, but we can act accordingly to make things better.


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